ChromasterUltra Rs UHPLC System
Ultra High-Performance Liquid Chromatography with Uncompromising Speed, Sensitivity & Resolution
The ChromasterUltra Rs UHPLC system by Hitachi High-Tech is designed to meet the growing demand for faster analysis, greater resolution, and enhanced sensitivity in modern laboratories. Combining advanced pressure tolerance, high-speed detection, and excellent chromatographic reproducibility, this next-generation system delivers robust and precise performance across a wide range of analytical fields.
With the ability to operate up to 140 MPa (1400 bar) and supporting column particle sizes as small as 1.5 μm, the ChromasterUltra Rs offers outstanding resolution while shortening run times — making it ideal for pharmaceutical R&D, quality control, environmental monitoring, and complex sample matrices.
🔍 Key System Features
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Ultra-high pressure binary gradient pump (up to 140 MPa)
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High-resolution separations using sub-2 μm particles
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Autosampler with ultra-low carry-over (≤0.001%) and flexible vial/plate compatibility
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Advanced Diode Array Detector (DAD) with fast 100 Hz sampling and wide dynamic range
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Precision oven with Peltier control, supporting column switching and consistent thermal environments
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Compact modular design, optimized for integration, maintenance, and expansion
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Compliant with GLP/GMP and suitable for 21 CFR Part 11 regulated environments
⚙️ Module Descriptions
🔹 6170 Binary Pump
A high-pressure binary gradient pump with ultra-low internal volume and outstanding gradient accuracy. It features a double corkscrew mixer for rapid and stable gradient formation, and a 6-channel degassing unit. Operates at up to 140 MPa with flow rates ranging from 0.001 to 2.0 ml/min (up to 1400 bar) and up to 2.5 ml/min (up to 800 bar).
🔹 6270 Autosampler
Equipped with loop offline mode and exceptional carry-over suppression (≤0.001%), the autosampler supports various vial and microplate formats:
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Up to 195 x 1 ml vials (optional)
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120 x 1.5 ml, 72 x 4 ml vials
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2 x MTP (96 or 384 wells)
Optional cooling unit ensures sample stability for thermally sensitive compounds.
🔹 6310 Column Oven
Precision-controlled oven with Peltier thermal control, supporting ambient ±15 to +85°C. The oven can accommodate multiple columns and includes optional 2-position/6-port valve for column switching. MEM-compatible fittings allow for minimal dead volume.
🔹 6430 DAD Detector
High-sensitivity Diode Array Detector (DAD) with 190–650 nm detection range and 1024-element photodiode array. Features a 65 mm high-sensitivity flow cell, total reflection capillary design, and 100 Hz data acquisition rate for sharp, high-resolution peak detection.
🧪 Typical Applications
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Impurity profiling and assay in pharmaceutical development
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Method transfer and scale-down from HPLC to UHPLC
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Analysis of complex biological samples and protein/peptide mixtures
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Fast gradient elution for high-throughput QC
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Detection of trace contaminants in food, cosmetics, and environmental samples
Technical Specifications – ChromasterUltra Rs UHPLC System
Module |
Max Pressure |
Flow Rate Range (ml/min) |
Sample Capacity |
Temp Range (°C) |
Detection Range / Type |
Noise / Drift |
Key Features |
|---|---|---|---|---|---|---|---|
| 6170 Binary Pump | 1400 bar (140 MPa) | 0.001–2.0 (1400 bar), 0.001–2.5 (800 bar), 0.001–5.0 (purge) | – | – | – | – | Binary gradient, mixer, degasser, seal wash |
| 6270 Autosampler | 1400 bar (140 MPa) | – | 195×1 ml (opt), 120×1.5 ml, 72×4 ml (opt), 2× MTP (96/384 wells) | with cooling function | – | – | ≤0.001% carry-over, loop mode, GUI, wash system |
| 6310 Column Oven | – | – | – | Ambient ±15 to +85 | – | – | Peltier control, valve switching option, MEM fitting |
| 6430 DAD Detector | 60 bar (6 MPa) | – | – | – | 190–650 nm, 1024-bit diode array | Low noise, low drift | 65 mm cell, capillary flow, 100 Hz acquisition rate |
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