PTWS 820-MA

Introducing the PTWS 820-MA by Pharma Test

Overview

The PTWS 820-MA by Pharma Test is an advanced, automated 8-position USP/EP tablet dissolution testing instrument with a media addition station, specifically designed for testing delayed release dosage forms. This innovative system ensures precise and reproducible results by automating the media half-change process, which is crucial for the accurate assessment of enteric-coated and delayed-release tablets.

Key Features

1. Automated Media Addition: The PTWS 820-MA automates the addition of 250 mL of pre-heated buffer solution to the dissolution vessels, significantly reducing manual intervention and ensuring consistency in test conditions. This feature is particularly useful for tests requiring media changes after a set period, such as 2 hours in 0.1N HCl followed by a switch to a buffer solution.
2. Compliance: Fully compliant with USP <711>, EP <2.9.3>, and CP <931> standards, this system meets stringent pharmaceutical testing requirements, ensuring reliable and accurate dissolution testing for delayed release dosage forms.
3. Temperature Control: The system includes a sophisticated heating mechanism to preheat the buffer to 37°C, maintaining the required temperature tolerance of 37±0.5°C in the dissolution vessels. This precise temperature control is vital for maintaining test integrity.
4. Efficient Operation: With the ability to add media in under 30 seconds using a gravity-fed valve system, the PTWS 820-MA enables quick transitions and reduces the potential for temperature fluctuations, thus maintaining the accuracy of the dissolution process.
5. Unattended Operation: The automated system allows for unattended operation, enabling users to start tests in the evening and return to complete results, saving time and labor.
6. Software Integration: The system can be controlled via the WinDiss ARGUS dissolution software, providing a user-friendly interface and ensuring compliance with data integrity requirements (21 CFR Part 11).

Technical Specifications

• Number of Vessels: 8 positions
• Vessel Material: 250 mL USP/EP Borosilicate glass, each individually coded
• Vessel Covers: Ultra-low evaporation design (< 0.7% within 24 hours)
• Heating System: Pump for water circulation and a 1500W heater
• Heater Range: 25-45°C with an accuracy of ± 0.2°C
• Dimensions: Bath – 60cm x 25cm x 64cm; Heater – 26cm x 37cm x 21cm
• Weight: Approx. 12kg for the water bath, 5kg for the heater

Advantages

• Speed and Efficiency: The fast buffer addition (500 mL/min) ensures that the test proceeds immediately after the specified time, maintaining compliance with USP and EP guidelines.
• Precision and Accuracy: Automated temperature checks and logging at all sampling times enhance the reliability of results.
• Ease of Use: The integration with WinDiss ARGUS software simplifies the operation, making it accessible even for less experienced users.

Conclusion

The PTWS 820-MA is an essential tool for pharmaceutical laboratories focused on the rigorous testing of delayed-release and enteric-coated dosage forms. Its automated features, compliance with international standards, and advanced software integration make it a standout choice for ensuring the accuracy and efficiency of dissolution testing.

For more information or to request a quote, please contact our sales team